CHEMICAL SUBSTANCE DATASHEET
CHEMICAL SUBSTANCE IDENTIFICATION |
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Chemical name |
Cadmium (elemental) [1] |
Main ions of the substance Key isotopes |
Cadmium +2 114Cd |
Synonyms |
Cadmium metal, Cadmium cation, Cadmium ion |
IUPAC name |
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CAS No |
7440-43-9 |
REACH registration number |
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EC No |
231-152-8 [2] |
Molecular formula |
Cd |
Substance group/chemical family |
Inorganic substances/transition metal |
Appearance Physical state Odour Form Colour |
solid odourless
silvery-white, bluish white [1] |
USES AND HANDLING ISSUES |
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Relevant identified uses |
manufacture of batteries, electrical conductors and metal plating [2].
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Handling considerations |
Processes and operations which may release cadmium fumes or dust should be enclosed and fitted with exhaust ventilation if practicable. Workers should wear a high efficiency particulate filter respirator or self-contained breathing apparatus in activities where over-exposure is possible. Protective clothing and gloves also should be worn, and these should be removed before leaving work. If contact should occur, immediately wash contaminated skin with large amounts of water. Do not eat, smoke, or drink in work areas. Cadmium should be stored in closed containers, away from sources of physical damage. [1] |
PHYSICO-CHEMICAL PROPERTIES |
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Molecular weight |
112.41 g/mol [1] (Cd elemental) |
Bulk density/Specific gravity |
8.69 g/cm3 at 25 °C [1] |
pH |
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EC |
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Melting point |
309 - 326 °C @ 101.325 kPa [6], 321°C [1] |
Boiling point |
767 °C (Cd elemental) [1] |
Flash point |
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Flammability |
Non-combustible solid in bulk form, but will burn in powder form. 250°C (cadmium metal dust) [2] |
Vapour density |
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Vapour pressure |
0 mmHg (approx) [8]
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Solubility in water |
insoluble (Cd elemental) [1] 2.3 - 8.7 mg/L @ 20 °C and pH 7.23 - 8.94 [6] |
Solubility in organic solvents |
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Hydrolysis |
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Ionicity in water |
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Surface tension |
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Dispersion properties Simple Compounds |
Nitrides (Cd3N2), Sulfides (CdS), Selenides (CdSe), Tellurides (CdTe), Hydrides (CdH2), Fluorides (CdF2), Chlorides (CdCl2), Iodides (CdJ2), Oxides (CdO, CdO2) [12] |
Stability and reactivity |
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Chemical stability |
Slowly oxidized by moist air to form cadmium oxide [2]. |
Reactivity hazards |
Cd reacts with acids. This produces flammable/explosive gas (hydrogen). The dust reacts with oxidants, hydrogen azide, zinc, selenium and tellurium. This generates fire and explosion hazard [2]. |
Corrosivity |
Corrosion resistance poor in industrial atmosphere [1] |
Polimerization |
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Incompatibility with various substances |
Strong oxidizers; elemental sulfur, selenium & tellurium |
Special remarks on reactivity | The dust ignites spontaneously in air and is flammable and explosive when exposed to heat [2]. When reactive gases or vapour, such as carbon dioxide, water vapour, sulfur dioxide, sulfur trioxide or hydrogen chloride are present, cadmium vapour reacts to produce cadmium carbonate, hydroxide, sulfite, sulfate or chloride, respectively [3]. |
Physical, chemical and biological coefficients |
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Koc |
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Kow |
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pKa |
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Henry-constant |
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ENVIRONMENTAL FATE AND BEHAVIOUR |
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Artificial pollution sources |
Liberation during smelting and refining of ores where it is a by-product of zinc, lead and copper bearing ores. Liberation during recovery of metal by processing scrap; during melting and pouring of cadmium metal; during casting of alloys for cadmium-copper, cadmium-lead, cadmium-bismuth, cadmium-silver, cadmium-nickel, cadmium-lead-silver, cadmium-lead-silver-nickel, cadmium-lead-bismuth-tin, and cadmium-gold products used for coating telephone cables, trolley wires, welding, electrodes, automatic sprinkling systems, steam boilers, fire alarms, high pressure/temperature bearings, starting switches, aircraft relays, light duty circuit breakers, low temperature solder, and jewellery. Liberation during fabrication of metal, alloys, or plated steel. Liberation during casting and use of solders; during melting of cadmium ingots for paint and pigment manufacture used for colouring of plastics and ceramic glazes, electroplating, and in chemical synthesis. Liberation during coating of metals by hot dipping or spraying. Liberation during manufacture of nickel-cadmium batteries for use in radio portable telephones, convenience appliances, and vented cells used in airplanes, helicopters, and stand-by power and lighting [1]. |
General terrestrial fate |
In all soil types, Cd activity is strongly affected by pH; it is more mobile in acidic soil within the pH range of 4.5 to 5.5, and its solubility is largely controlled by organic matter and sesquioxides. In alkaline soil, Cd is rather immobile and precipitation of Cd compounds occur. The critical acidity in mineral soil is between pH 4.0 to 4.5, at which a drop in pH of merely 0.2 units results in a 3 to 5 times increase of Cd concentration in soil solutions. Cd readily forms complexes in solution with halides, cyanides and ammonium species, and has a strong affinity for organic matter [10]. |
General aquatic fate |
high mobility especially during conditions of elevated flow, when pH is lower [10]. |
General atmospheric fate |
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General persistence and degradability |
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Abiotic degradation and metabolites |
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Biodegradation and metabolites |
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Bioconcentration | The free metal ion, Cd2+, is the form most available to aquatic species. Organisms in the freshwater environment are contaminated according to their ability to absorb or adsorb cadmium from the water. Conversely, marine organisms take up cadmium principally from food. The primary source of cadmium in terrestrial systems is the soil, and uptake follows the typical food chain pathway [4]. |
Volatilization |
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Photolysis |
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Hydrolysis |
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Soil adsorption and mobility |
In the surface environment, Cd is most mobile under oxidising conditions at pH levels below 8. |
ENVIRONMENTAL CONCENTRATIONS | |
Measured data |
Cadmium is a widely but sparsely distributed element found in the earth's crust at concentrations ranging from 0.1 to 0.5 ppm, primarily as sulfide minerals in association with zinc ores, zinc-bearing lead ores, and complex copper-lead-zinc ores. Greenocktite (CdS) is found associated with zinc ore, sphalerite (ZnS); zinc carbonate contains otavite (CdCO3) in small amounts. Cadmium abundance in seawater is estimated as 0.11 ug/L[1]. Cadmium values in stream water range from <0.002 to 0.53 μg /L. The median Cd content is 0.09 mg kg-1 in subsoil and 0.145 mg/kg in topsoil; the range varies from < 0.01 to 14.2 mg/kg in subsoils and up to 14.1 mg/kg in topsoils. The average ratio topsoil/subsoil is 1.477. The median Cd content in stream sediment is 0.29 mg/kg, and the range varies from <0.02 to 43.1 mg/kg [10]. |
ECOTOXICOLOGICAL INFORMATION |
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General adverse effects on ecosystem |
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Acute toxicity (LC50, EC50) |
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Aquatic systems
Terrestrial systems |
LC50=16 µg Cd/L, (96 hr) (flow system) Mortality, Mysidopsis bahia (adult shrimp) [4]
LC50=1.62 mg Cd/L, (96 hr) (static) Mortality, Mytilus edulis planulatis (mussel) [4]
LC50<1 mg Cd/L, (8 hr) Tetrahymena pyriformis (freshwater protozoan) [4]
LC50 (24 days) 34 - 2 300 µg/L (fish) [6]
LC50 (4 days) 748 - 6 470 µg/L (fish) [6]
EC50 (24 h) 1.9 mg/L (aquatic invertebrates) [6]LC50 (48 days) 110 - 750 µg/L (aquatic invertebrates)[6] LC50 (4 days) 5 - 1 820 µg/L (aquatic invertebrates)[6] LC50 (72 h) 8.88 µg/L (aquatic invertebrates)[6] LC50 (60 h) 15.8 µg/L (aquatic invertebrates)[6] EC50 (72 h) 18 - 120 µg/L aq. algae & cyanobacteria [6] |
Chronic toxicity (NOEC, LOEC) | |
HUMAN HEALTH EFFECTS and PROTECTION | |
Routes of human exposures |
inhalation from ambient air and working environment;
the smoking of tobacco;
ingestion from drinking water and food;
hand-to-mouth route for children;
absorption via skin;
absorption via intestinal tract;
absorption via inhalation [3].
|
General effects |
pulmonary edema, dyspnea (breathing difficulty), cough, chest tightness, substernal (occurring beneath the sternum) pain; headache; chills, muscle aches; nausea, vomiting, diarrhea; anosmia (loss of the sense of smell), emphysema, proteinuria, mild anemia [8]. |
Endocrine disruption |
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Mutagenicity Genotoxicity |
Cadmium, when given at a dose of 10µmol/l or 1.83 µg/ml for 2 weeks, can induce malignant transformation of human or rat prostatic epithelial cells in vitro [7] |
Carcinogenicity |
Cadmium and cadmium compounds are carcinogenic to humans (Group 1) [1]. |
Reprotoxicity Developmental toxicity |
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Teratogenicity |
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Skin, eye and respiratory irritations |
It is irritating to the nose and throat [1]. |
Metabolism: absorption, distribution & excretion |
The absorption or bioavailability of cadmium from the gastrointestinal tract is generally considered to be slightly lower in experimental animals than in humans. For the majority of species tested, the absorption of cadmium can range from 0.5% to 3.0% of the dose administered, while in humans a range of 3.0–8.0% can be found [7]. |
Exposure limits |
(DNEL) 4 µg/m³ (inhalation) (repeated dose toxicity, workers) [6] (DNEL) 1 µg/kg bw/day (oral) (repeated dose toxicity, general population) [6] (TWA) 0.005 mg/m3 [8] |
Drinking water MAC |
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Other information |
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Animal toxicity data |
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Acute toxicity (LD50) |
LD50 63 - 2 330 mg/kg bw (rat) (oral)[6] LD50 63 - 890 mg/kg bw (mouse) (oral) [6] LC50 (3 h) 4.6 - 8.4 mg/m³ air (rat) (inhalation)[6] LC50 (2 h) 4.5 - 132 mg/m³ air (rat) (inhalation)[6] LC50 (30 min) 8.63 mg/m³ air (rat) (inhalation)[6]] LC50 (15 min) 9.02 mg/m³ air (mouse) (inhalation)[6] LC50 (2 h) 4.5 mg/m³ air (inhalation)[6] |
Chronic toxicity (NOEL, LOEL) |
NOAEL (rat): 0.2 - 3 mg/kg bw/day (oral) [6] NOAEL (dog): 0.75 mg/kg bw/day (oral) [6] LOAEL (rat): 0.5 mg/kg bw/day (oral) [6] NOAEL (rat): 25 µg/m³ air (inhalation) [6] NOAEL (hamster): 10 µg/m³ air (inhalation) [6] LOAEL (rat): 50 µg/m³ air (inhalation) [6] |
ENVIRONMENTAL STANDARDS AND REGULATIONS | |
EINECS regulation |
̵ 231-152-8 |
OSHA regulations etc.
NIOSH
|
OSHA has set the permissible exposure limit (PEL) for cadmium at a time-weighted average (TWA) [8] The National Institute for Occupational Safety and Health (NIOSH) has not set a recommended exposure limit (REL) and has designated cadmium as a known human carcinogen [8] |
REACH regulation COMMISSION REGULATION (EC) No 1881/2006 of 19 December 2006 |
The supply and use of cadmium is restricted in Europe [5] Current maximum levels for cadmium in certain foods are laid down [11] |
OTHER INFORMATION, SPECIAL REMARKS | |
Classification and proposed labelling with regard to toxicological data |
According to the classification provided by companies to ECHA in REACH registrations this substance is fatal if inhaled, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, may cause cancer, causes damage to organs through prolonged or repeated exposure, is suspected of causing genetic defects, is suspected of damaging fertility or the unborn child and catches fire spontaneously if exposed to air [5]. |
CREATED, LAST UPDATE |
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Created |
4th of July, 2018 |
Last update |
6th of July, 2018 |
REFERENCES |
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[1] TOXNET – Toxicology Data Network. Available from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~6wVkBb:3, Accessed: 4th of July, 2018 [2] PUBCHEM - NIH, US National Library of Medicine, National Center for Biotechnology Information, Open Chemistry Database, Available from: https://pubchem.ncbi.nlm.nih.gov/compound/cadmium#section=Canonical-SMILES, Accessed: 4th of July, 2018 [3] INCHEM - International Programme on Chemical Safety, Environmental Health Criteria 134, Available from: http://www.inchem.org/documents/ehc/ehc/ehc134.htm, Accessed: 4th of July, 2018. [4] INCHEM - International Programme on Chemical Safety, Environmental Health Criteria 135, Available from: http://www.inchem.org/documents/ehc/ehc/ehc135.htm, Accessed: 5th of July, 2018 [5] European Chemicals Agency (ECHA). Substance information. Available from: https://echa.europa.eu/hu/substance-information/-/substanceinfo/100.028.320, Accessed: 5th of July, 2018. [6] European Chemicals Agency (ECHA). Substance information. Available from: https://echa.europa.eu/hu/brief-profile/-/briefprofile/100.028.320, Accessed: 5th of July, 2018. [7] INCHEM - International Programme on Chemical Safety, Environmental Health Criteria, Available from http://www.inchem.org/documents/jecfa/jecmono/v52je22.htm#gen, Accessed: 5th of July, 2018. [8] NIOSH. NIOSH Pocket Guide to Chemical Hazards. Cadmium dust (as Cd), Available from: https://www.cdc.gov/niosh/npg/npgd0087.html, Accessed: 5th of July, 2018. [9] 2002/95/EC (RoHS) - European Commission Decision of 12 October 2006 amending, for the purposes of adapting to technical progress, the Annex to Directive 2002/95/EC of the European Parliament and of the Council as regards exemptions for applications of lead and cadmium (notified under document number C(2006) 4790)". Journal of the European Union. 14 October 2006. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2006:283:0048:0049:EN:PDF, Accessed: 5th of July, 2018. [10] Cadmium, Available from: http://weppi.gtk.fi/publ/foregsatlas/text/Cd.pdf , Accessed: 5th of July, 2018. [11] Commission Regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs, Available from: http://data.europa.eu/eli/reg/2006/1881/2015-05-21, Accessed: 6th of July, 2018. [12] The Mineralogy of Cadmium, Available from: https://www.mindat.org/element/Cadmium, Accessed: 6th of July, 2018. |