Toxicity tests involving vertebrate animals or eliminating them

Testing proposals for chemical substances involving vertebrate animals

Regulation (EC) No 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) requires that information on toxic effects of substances is obtained by manufacturers and importers of substances. They can then assess the hazards of those substances and ensure that the risks are documented and controlled during their manufacture, use and disposal. However, REACH also requires that new testing of a substance involving vertebrate animals is only carried out as a last resort.

To ensure that the best use has been made of existing information, particularly information on existing vertebrate tests, the European Chemicals Agency’s (ECHA) publishes all test proposals involving vertebrate animals on this webpage before the testing is carried out. After a testing proposal has been published, third parties have 45 days to submit "scientifically valid information and studies that address the relevant substance and hazard endpoint, relating to the testing proposal" (REACH, Article 40 (2)).

Information on these registered substances is published at ECHA website
http://echa.europa.eu/consultations/test_proposals/test_prop_cons_en.asp